Endocrine Abstracts

Recent data have shown that, in parallel to its transcriptional action down-regulating TSH synthesis, triiodothyronine (T3) also acts on posttranscriptional steps of beta TSH synthesis, reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized rats. This study aimed to investigate whether these effects also occur in TalphaT1 cells, and if they are dependent on gene transcription, which would characterize ...

Thyroid nodules are common and majority is benign. Even so, clinicians and patient always concern about the risk for malignancy. In the past it was believed that hyperthyroidism excluded the possibility of a thyroid carcinoma. We describe here two patients presenting “hot” thyroid nodules with final diagnosis of papillary thyroid carcinoma. Informed consent was obtained. Case 1: A 39-years-old female, presenting with irritability, disquiet, and neck swelling. A nodul...

Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances on the reproductive development of male offspring from dams treated during th...

Several studies demonstrated that the thyroid hormones (TH) downregulate the transcriptional rate of beta and alpha TSH subunits. Recent data showed that T3 also acts posttranscriptionally reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized (Tx) rats. This study aimed to investigate whether similar effects occur for the alpha subunit synthesis after acute administration of T3 or T4</...

Aim: HMβ is a metabolite of leucine commonly used by athletes and in medical practice in order to increase muscle mass and/or minimize protein degradation. We have previously shown that chronic intake of HMβ increases GH synthesis and secretion in rats, which might account to its anabolic effect. However HMβ-treated rats, although normoglycemic, exhibited hyperinsulinemia, suggesting an apparent insulin resistance (IR) state. The present study attempted to inves...

Study aim: Pituitary function evaluation in patients with traumatic brain injury (TBI).Subjects: One hundred and forty-six patients (49 female, 97 men, age: 31.9±16.2 years) recovered from moderate to severe TBI. Prospective follow up has been performed 3/6 and 12 months from TBI for 79 subjects. Retrospective evaluation (from 0.3 to 30 years) included 67 subjects selected in front of overt clinical features (obesity, fatigue, sexual disorders)....